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Title   All - Trans Retinoic Acid 에 의한 HL - 60 세포 분화유도중 H2B Histone , c-Myc 및 DNA Topoisomerase 1 발현에 관한 연구 ( Studies on the H2B Histone , c-Myc and DNA Topoisomerase 1 Gene Expression during HL - 60 Differentiation by All - Trans Retinoic Acid )
Publicationinfo   1994 Jan; 026(02): 285-296.
Key_word   All-trans retinoic acid, H2B histone, c-myc, DNA topoisomerase I
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Abstract   Effects of all-trans retinoic acid(retinoic acid) on DNA replication, H2B histone and DNA topoisopmerase I(Topo I) gene expression have been investigated in human promyelocytic leukemia cell line HL-60. DNA synthesis decreased at 24 hours after exposure of retinoic acid in the HL-60 cells. H2B histone mRNA rapidly reduced at 48 hours and Topo I and c-myc mRNA at 24 hours in retinoic acid-exposured HL-60 cells, respectively. The levels of c-myc, H2B his- tone and Topo I gene expression were reduced in proportion to the concentration of retinoic acid. The H2B histone mRNA in retinoic acid-exposured cells was elevated by cycloheximide treatment, while the level of Topo I mRNA was constant. These results suggest that regulations of H2B histone, c-myc and Topo I gene expression are different from one another, and repression of Topo I gene is closely correlated with c-myc gene during retinoic acid-induced differentiation of HL-60 cells.
저 자   임규(Kyu Lim),박정동(Jeong Dong Park),최병한(Byung Han Choi),이용진(Young Jin Lee),김계영(Kye Young Kim),이명선(Myung Sun Lee),장은미(Eun Mi Chang),김삼용(Sam Yong Kim),권기량(Gi Ryang Kweon),곽상태(Sang Tae Kwak),황병두(Byung Doo Hwang)